Biochemistry sem 2 | Download best B pharmacy Second-year notes free | download pharmacy notes pdf semester wise
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UNIT I
· Biomolecules Introduction,
classification, chemical nature and biological role of carbohydrate, lipids,
nucleic acids, amino acids and proteins.
· Bioenergetics Concept of free energy,
endergonic and exergonic reaction, Relationship between free energy, enthalpy
and entropy; Redox potential.
Energy rich compounds; classification; biological
significances of ATP and cyclic AMP
UNIT II
· Carbohydrate metabolism
Glycolysis – Pathway, energetics and significance
Citric acid cycle- Pathway, energetics and
significance
HMP shunt and its significance; Glucose-6-Phosphate
dehydrogenase (G6PD) deficiency Glycogen metabolism Pathways and glycogen
storage diseases (GSD)
Gluconeogenesis- Pathway and its significance Hormonal
regulation of blood glucose level and Diabetes mellitus
· Biological oxidation
Electron transport chain (ETC) and its mechanism.
Oxidative phosphorylation & its mechanism and
substrate phosphorylation
Inhibitors ETC and oxidative
phosphorylation/Uncouplers level
UNIT III
· Lipid metabolism
β-Oxidation of saturated fatty acid (Palmitic acid)
Formation and utilization of ketone bodies;
ketoacidosis
De novo synthesis of fatty acids (Palmitic acid)
Biological significance of cholesterol and conversion
of cholesterol into bile acids, steroid hormone and vitamin D
Disorders of lipid metabolism: Hypercholesterolemia,
atherosclerosis, fatty liver and obesity.
· Amino acid metabolism General reactions of
amino acid metabolism: Transamination, deamination & decarboxylation,
urea cycle and its disorders
Catabolism of phenylalanine and tyrosine and their
metabolic disorders (Phenyketonuria, Albinism, alkeptonuria, tyrosinemia)
Synthesis and significance of biological substances;
5-HT, melatonin, dopamine, noradrenaline, adrenaline
Catabolism of heme; hyperbilirubinemia and jaundice
UNIT IV
· Nucleic acid metabolism and genetic
information transfer
Biosynthesis of purine and pyrimidine nucleotides
Catabolism of purine nucleotides and Hyperuricemia and
Gout disease
Organization of mammalian genome
Structure of DNA and RNA and their functions
DNA replication (semi-conservative model)
Transcription or RNA synthesis
Genetic code, Translation or Protein synthesis and inhibitors
UNIT V
· Enzymes
Introduction, properties, nomenclature and IUB
classification of enzymes Enzyme kinetics (Michaelis plot, Line Weaver Burke
plot)
Enzyme inhibitors with examples
Regulation of enzymes: enzyme induction and
repression, allosteric enzymes regulation Therapeutic and diagnostic
applications of enzymes and isoenzymes
Coenzymes –Structure and biochemical functions
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Following chapters:-
UNIT I
· Biomolecules Introduction, classification, chemical nature and biological role of carbohydrate, lipids, nucleic acids, amino acids and proteins.
00.Unit 1 all chaptors
Download (Optional link)
01 Introduction to Biochemistry
02.Carbohydrates
03.Lipid
04.Protein
05.Amino Acid
· Bioenergetics Concept of free energy, endergonic and exergonic reaction, Relationship between free energy, enthalpy and entropy; Redox potential.
Energy rich compounds; classification; biological significances of ATP and cyclic AMP
Download (Coming Soon)
UNIT II
· Carbohydrate metabolism
Glycolysis – Pathway, energetics and significance
Citric acid cycle- Pathway, energetics and significance
HMP shunt and its significance; Glucose-6-Phosphate dehydrogenase (G6PD) deficiency Glycogen metabolism Pathways and glycogen storage diseases (GSD)
Gluconeogenesis- Pathway and its significance Hormonal regulation of blood glucose level and Diabetes mellitus
UNIT III
· Lipid metabolism
β-Oxidation of saturated fatty acid (Palmitic acid)
Formation and utilization of ketone bodies; ketoacidosis
De novo synthesis of fatty acids (Palmitic acid)
Biological significance of cholesterol and conversion of cholesterol into bile acids, steroid hormone and vitamin D
Disorders of lipid metabolism: Hypercholesterolemia, atherosclerosis, fatty liver and obesity.
· Amino acid metabolism General reactions of amino acid metabolism: Transamination, deamination & decarboxylation, urea cycle and its disorders
Catabolism of phenylalanine and tyrosine and their metabolic disorders (Phenyketonuria, Albinism, alkeptonuria, tyrosinemia)
Synthesis and significance of biological substances; 5-HT, melatonin, dopamine, noradrenaline, adrenaline
Catabolism of heme; hyperbilirubinemia and jaundice
UNIT IV
· Nucleic acid metabolism and genetic information transfer
Biosynthesis of purine and pyrimidine nucleotides
Catabolism of purine nucleotides and Hyperuricemia and Gout disease
Organization of mammalian genome
Structure of DNA and RNA and their functions
DNA replication (semi-conservative model)
Transcription or RNA synthesis
Genetic code, Translation or Protein synthesis and inhibitors
UNIT V
· Enzymes
Introduction, properties, nomenclature and IUB classification of enzymes Enzyme kinetics (Michaelis plot, Line Weaver Burke plot)
Enzyme inhibitors with examples
Regulation of enzymes: enzyme induction and repression, allosteric enzymes regulation Therapeutic and diagnostic applications of enzymes and isoenzymes
Coenzymes –structure and biochemical functions
Download (Optional link)
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