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Scope: This subject is designed to impart knowledge and skills of Biopharmaceutics and pharmacokinetics and their applications in pharmaceutical development, design of dose and dosage regimen and in solving the problems arised therein.
Objectives:
1. Understand the basic concepts in biopharmaceutics and pharmacokinetics and their significance.
2. Use of plasma drug concentration-time data to calculate the pharmacokinetic parameters to describe the kinetics of drug absorption, distribution,metabolism, excretion, elimination.
3. To understand the concepts of bioavailability and bioequivalence of drug products and their significance.
4. Understand various pharmacokinetic parameters, their significance & applications
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Semester 1 :- Click here
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Semester 3 :- Click here
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Syllabus Content:
Unit I
Introduction to Biopharmaceutics
Absorption; Mechanisms of drug absorption through GIT, factors influencing drug
absorption though GIT, absorption of drug from Non per oral extra-vascular routes,
Distribution Tissue permeability of drugs, binding of drugs, apparent, volume
of drug distribution, plasma and tissue protein binding of drugs, factors affecting
protein-drug binding. Kinetics of protein binding, Clinical significance of protein
binding of drugs
Unit II
Elimination: Drug metabolism and basic understanding metabolic pathways renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal routes of drug excretion of drugs
Bioavailability and Bioequivalence: Definition and Objectives of bioavailability, absolute and relative bioavailability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and bioavailability of poorly soluble drugs.
Unit III
Pharmacokinetics:- Definition and introduction to Pharmacokinetics, Compartment models, Non compartment models, physiological models, One compartment open model.
(a). Intravenous Injection (Bolus)
(b). Intravenous infusion and
(c) Extra vascular administrations. Pharmacokinetics parameters - KE ,t1/2,Vd,AUC,Ka, Clt and CLR- definitions methods of eliminations, understanding of their significance and application
Unit IV
Multicompartment models:
Two compartment open model. IV bolus Kinetics of multiple dosing, steady state drug levels, calculation of loading and mainetnance doses and their significance in clinical settins.
Unit V
Nonlinear Pharmacokinetics:
a. Introduction,
b. Factors causing Non-linearity.
c. Michaelis-menton method of estimating parameters, Explanation with example of drugs.
Download Following Chapters:-
Unit I
Introduction to Biopharmaceutics
Absorption; Mechanisms of drug absorption through GIT, factors influencing drug
absorption though GIT, absorption of drug from Non per oral extra-vascular routes,
Distribution Tissue permeability of drugs, binding of drugs, apparent, volume
of drug distribution, plasma and tissue protein binding of drugs, factors affecting
protein-drug binding. Kinetics of protein binding, Clinical significance of protein
binding of drugs
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Unit II
Elimination: Drug metabolism and basic understanding metabolic pathways renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal routes of drug excretion of drugs
Bioavailability and Bioequivalence: Definition and Objectives of bioavailability, absolute and relative bioavailability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and bioavailability of poorly soluble drugs.
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Unit III
Pharmacokinetics:- Definition and introduction to Pharmacokinetics, Compartment models, Non compartment models, physiological models, One compartment open model.
(a). Intravenous Injection (Bolus)
(b). Intravenous infusion and
(c) Extra vascular administrations. Pharmacokinetics parameters - KE ,t1/2,Vd,AUC,Ka, Clt and CLR- definitions methods of eliminations, understanding of their significance and application
Download
Download (optional link)
Unit IV
Multicompartment models:
Two compartment open model. IV bolus Kinetics of multiple dosing, steady state drug levels, calculation of loading and mainetnance doses and their significance in clinical settins.
Download
Download (optional link)
Unit V
Nonlinear Pharmacokinetics:
a. Introduction,
b. Factors causing Non-linearity.
c. Michaelis-menton method of estimating parameters, Explanation with example of drugs.
MCQs on Introduction of Glycosides:-Click here
MCQs on Introduction of pharmacognosy :- Click here
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MCQs From Pharmaceutical Engineering (include all chapters):- Click here
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MCQs From Pharmaceutical Jurisprudence (include all chapters):-Click here
MCQs on Introduction of Alkaloids:- Click here
Human Anatomy and Physiology-I :- Click here
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