Biopharmaceutics and Pharmacokinetics sem 6 part 2 (51-100) MCQs with Answers for B pharmacy students as per PCI Syllabus | Free MCQs for GPAT and NIPER
Follow us on :-
Facebook:- Click here
Instagram:- Click here
Youtube:- Click here
Telegram:- Click here
51. What does the interfacial barrier model states?
a) An intermediate concentration exists at the interface
b) Turbulence in the dissolution medium exists at the solid/liquid interface
c) Formation a thin film or layer at the solid-liquid interface
d) Solutes passes easily through the interfaces
52. In the equation, Wol/3-W1/3=Kt, K stands for.
a) The original mass of the drug
b) Mass of the drug remaining after time t
c) Dissolution constant
d) Concentration of solute
53. Which are the two rate-determining step of drug absorption when given orally?
a) Disintegration and deaggregation
b) Disintegration and Dissolution
c) Dissolution and permeation through the membrane
d) Permeation through the membrane and Disintegration
54. The maximum amount of solute dissolved in a given solvent under standard
conditions oftemperature, pressure, and pH is known as
a) Dissolution rate
b) Intrinsic dissolution
c) Rate limiting step
d) Absolute or intrinsic solubility
55. Which option will be the best example of the physicochemical properties of drugs?
a) Solubility, particle size, polymorphism, salt form, pseudopolymorphism,
complexation, wettability, pH, Pressure of disintegration
b) Pressure of disintegration, polymorphism, salt form, pseudopolymorphism,
complexation, wettability, pH
c) Solubility, particle size, polymorphism, salt form
d) Solubility, particle size, polynmorphism, salt form, pseudopolymorphism,
complexation, wettability
56. For oral formulation, what should be the minimum aqueous solubility to avoid
bioavailability problems?
a) 0.9%
b) 1%
c) 2%
d) 0.11%
57. The total solid surface area of any particle is known as.
a) Absolute surface area
b) Effective surface area
c) Total surface area
d) Surface area
58. In the case of hydrophobic drugs, micronization results in a decrease in effective
surface area and thus fall is dissolution rate. Which of the below sentences cannot be a
reason for the given statement?
a) The hydrophobic surface of the drugs adsorbs onto their surface which inhibits their
wettability
b) The particles reaggregate to form larger particles due to their high surface free energy
c) Extreme reduction in the particle size imparts surface charges that may prevent wetting
d) Extreme reduction in the size brings the hydrophobic amino acids to the surface
59. How the absolute surface area of hydrophobic drugs can be converted to their
effective surface area?
a) Use of surfactant
b) Use of Hydrophobic diluents
c)Use ofsurfactant and hydrophilic diluents
d) No need of doing micronization
60. The solvate can exist in different crystalline forms called as
a) Solvates
b) Pseudopolymorphs
c) Pseudopolymorphism
d) Hydrate
61. Which form of a drug has greater solubility?
a) Anhydrous
b) Hydrate
) Crystallised
d) Monohydrate
62. Which one will be the easiest approach to enhance the solubility and dissolution of
any drug?
a) Micronize the drug
b) Convert drug into their anhydrous form
c) Convert drug into their hydrous form
d) Convert drug into their salt form
63. What is pH?
a) -ve log of H+ concentration
b) +ve log of H+ concentration
c) Log ofH+ concentration
d) H+ concentration
64. Which one of these is not an advantage of buffered aspirin tablets?
a) Enhanced bioavailability
b) Reduced gastric irritation
c) Increased stability
d) Inereased ulcerogenic tendeney
65. According to the pH-partition hypothesis which one of the given options doesn't
govern the absorption?
a) The molecular size of the drug
b) PH at the absorption site
c) Lipid solubility of unionized drugs
d) Dissociation constant
66. Which of the following equations correct for Henderson-Hasselbach equation for
weak acids?
a) PH = pKa- log (Unionized drug concentration /lonized drug concentration)
b) PH pKa- log (Ionized drug concentration/ Unionized drug concentration)
c) PH =pKa + log (Ionized drug concentration/ Unionized drug concentration)
d) PH = pKa + log (Unionized drug concentration Nonized drug concentration)
67. Which of the following equations correct for Henderson-Hasselbach equation for
weak bases?
a) PH = pKa- log (Unionized drug concentration /lonized drug concentration)
b) PH = pKa- log (lonized drug concentration/ Unionized drug concentration)
c) PH pKa + log (lonized drug concentration/ Unionized drug concentration)
d) PH = pKa + log (Unionized drug concentration lonized drug concentration)
68. What is the pH range of the stomach?
a) 1-4
b) 5-8
c) 1-3
d) 1-8
69. Which one of these is an example of a strong acid drug?
a) Diazepam
b) Ibuprofen
c) Cromolyn
d) Aspirin
70. Which one of these is not an example of a basic drug with pKa range 5-11?
a) Cromolyn
b) Imipramine
c) Amitriptyline
d) Chloroquine
71. Example of a drug which has PKa> 11 is
a) Cromolyn
b) Imipramine
c) Amitriptyline
d) Mecamylamine
72. Tbuprofen a weak acid, in the stomach will be present in which of the given form?
a) lonized form mostly
b) Non-ionized form mostly
c) Half ionized and half no ionized
d) Will form aggregate
73. Nitrazepam a weak base, will be in which form in the stomach?
a) lonized form mostly
b) Non-ionized form mostly
c) Half ionized and half no ionized
d) Will form aggregate
74. Who has more intracellular and extracellular water more in their body?
a) Aged
b) Adults Of age more than 20
c) Infants
d) Children at puberty
75. Who has higher fat content?
a) Adults of age above 70
b) Adults of age more than 20
c) Infants and elders
d) Children at puberty
76. Who has poorly developed BBB?
a) Infants
b) Adults Of age more than 20
c) Aged
d) Children at puberty
77. During pregnancy, drug distribution is more. Which of the following sentences
describe the given fact better?
a) The baby needs more drug
b) The mother needs more drug due to high metabolism
c) The surface area increases in the mother's body due to the presence of uterus, placenta,
and foetus. Thus more area for distribution of drugs
d) The growth of the uterus, placenta, and foetus increases the volume thus
increasing distribution. And even the baby forms a separate compartment for a
drug to get distributed
78. What happens when an obese person is given with a lipophilic drug?
a) Drug aggregation will begin
b) He cannot absorb lipophilic drugs
c) High adipose tissue
b) The patient can't be given with basic drugs
c) The basic drugs will aggregate and become poisonous for him
d) The high fatty acid level affeet the binding of acidic drugs
80. The extent to which a drug is distributed is a tissue depends upon and
a) The concentration of a drug, tissue/blood partition coefficient of drug
b) Tissue volume, tissue/blood partition coefficient of drug
c) Tissue surface area, tissue/blood partition coefficient of drug
d) Blood density upon the tissue, tissue/blood partition coefficient of drug
81. Which one of the following has a high perfusion rate?
a) Fat
b) Muscle and skin
c) Lungs and kidney
d) Bone
82. Which one of the following has very low perfusion rate?
a) Fat and bone
b) Muscle and skin
c) Lungs and kidney
d) Liver and Heart
83. In equation X=Vd C, what does Vd denotes?
a) Density
b) Volume of blood
c) Volume of body
d) The volume of the body fluid in which the drug is getting dissolved
84. The body water has 3 distinct compartments. Which one of these is not one of the
compartments?
a) Vascular fluid
b) Intracellular fluid
c) Extracellular fluid
d) Between the tissue layers
85. How can you determine the extracellular fluid volume?
a) Evans blue
b) Na+
c) D20
d) Tritiated water
86. What will bet the apparent volume of distribution of drugs which binds selectively to
extravascular tissues?
a) The apparent volume of distribution is less than the true volume of distribution
b) The apparent volume of distribution is more than the true volume of distribution
c) The apparent volume of distribution is equal to the true volume of distribution
d) The apparent volume of distribution is equal to the volume of extravascular tissues
87. Which one of the following bonds is not generally a bond through which a drug will
bind in our body?
a) Hydrogen bond
b) Hydrophobic bond
c) lonic bond
d) Covalent bond
88. Binding of drugs falls into 2 components those are
a) Binding of drugs to blood components and to extravascular tissue
b) Binding of drugs to blood components and to other cells
c) Binding of drugs to cells and blood cells
d) Binding of drugs to blood components to bones and cells
89. Which one of the following is the correct order of the drugs binding to various plasma
protein?
a) Albumin > alpha-1 acid glycoprotein > globulins > lipoproteins
b) Albumin> globulins > lipoproteins > alpha-1 acid glycoprotein
c) Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins
d) Albumin > lipoproteins > globulins > alpha-1 acid glycoprotein
90. What are xenobiotics?
a) Another form of antibiotics
b) A form of nutrient
c) Nutrients which kill the gut harmful microbes
d) Anything that is not nutrients and enters the body through different routes
91. What is the active form of salicylic acid?
a) Sialic acid
b) Salic acid
c) Salicylic acid
d) Salicycle acid
92. What are soft drugs?
a) Drugs given to babies
b) Chemical drugs which are already found in the body
c) Nutrients which kill the gut harmful microbes
d) Anything that is not nutrients and enters the body through different routes
93. Which of the following is the correct decreasing order of drug metabolism?
a) Liver > lungs > kidneys > intestine > placenta > skin > adrenals
b) Liver > lungs > kidneys > intestine > adrenals > placenta > skin
c) Liver >kidneys> lungs > intestine> placenta > adrenals > skin
d) Liver > lungs > intestine > kidneys > placenta> adrenals > skin
94. The enzymes are divided into two categories, these are, and.
a) Acidic drug metabolizing and basic drug metabolizing
b) Present in the liver and not present in the liver
c) Microsomal and non-mierosomal
d) There is no such division
95. Microsome are selective to
a) Water-soluble drugs
b) Lipid soluble drugs
c) Acidic drugs
d) Basic drugs
96. Where are non-microsomal enzymes present?
a) In the Golgi apparatus
b) Inside lysosomes
c) In the eytoplasm in soluble form
d) In oxysomes
97. Following are the Phase I reactions except.
a) Oxidative reactions
b) Hydrolytic reactions
c) Reductive reactions
d) Sulphide reactions
98. What is the major end product of oxidation of aromatic carbon atoms?
a) Arenols
b) Catechol
c) Glutathione
d) Arene oxide
99. Which one of the following is reactive and a known carcinogenic?
a) Cytochrome P-450
b) Catechol
c) Glutathione
d) Arene oxide
100. Which enzymes catalyses the hydrolysis of amides?
a) Esterase
b) Amydases
c) Amidases
d) Aminodases
MCQs From Hospital and Clinical Pharmacy(include all chapters): Click here
MCQs on Introduction of Glycosides:-Click here
MCQs on Introduction of pharmacognosy :- Click here
Download and Read B pharmacy MCQs :- Click here
MCQs on Introduction of Lipids and Resins:Click here
Medicinal Chemistry :-Click here
Organic chemistry:- Click here
Pharmaceutical Analysis:- Click here
Cosmetic Notes:- Click here
Pharmacology:- Click here
Pharmaceutics :- Click here
Pharmacognosy:- Click here
No comments:
Post a Comment